Nucleic Acid Therapeutics Synthesis
With over 15 years of dedicated experience in nucleic acid synthesis, BiOligo operates on a mature oligonucleotide chemistry platform supported by a comprehensive quality control system. Through continuous technical innovation, we provide high-purity oligonucleotides required across key development stages, including early discovery, in vivo studies, and process scale-up, offering a one-stop solution for small nucleic acid therapeutics development.
siRNA miRNA ASO Aptamer saRNA
Product Features
High Conjugation Efficiency
- Extensive experience in synthesis and conjugation, enabled by proprietary and innovative coupling technologies, achieving single-step coupling efficiencies of up to 99.6%
- 200+ modifications available, with multiple conjugation options including GalNAc, lipids, and small-molecule moieties
Comprehensive and Customizable Quality Control System
- 100+ QC methods available, covering LC-MS/MS, HPLC, chiral analysis, residual solvents, and endotoxin testing, .etc
- QC strategies can be tailored based on modification type, stereochemistry, and development stage, ensuring alignment with project-specific and regulatory expectations
High Purity
- Purified by 100% HPLC, with ≥90% purity, suitable for pharmacodynamic evaluation, delivery system assessment, and in vivo animal studies.
Flexible Synthesis Scale
- Oligonucleotide synthesis ranging from nmol to hundred-gram scale, supporting RUO through GMP-grade manufacturing requirements
Rapid Turnaround Time
- Standard research-grade oligonucleotides can be delivered within 3–7 business days, supporting rapid iteration during early-stage development
Reliability and Compliance
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Pharmaceutical GMP–certified manufacturing capabilities
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10+ invention patents and 20+ utility model patents related to nucleic acid synthesis, supported by additional proprietary and non-public technologies for specialized modifications and conjugation
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Validated siRNA silencing efficiency ≥75%
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Complete batch documentation and traceability system to support consistent and robust quality management
