APIs for Oligonucleotide Therapeutics

——Fast, high-purity, and professional oligonucleotide synthesis solutions to accelerate nucleic acid drug development.

With 15 years of expertise in nucleic acid synthesis, BiOligo leverages a mature oligonucleotide chemistry platform and comprehensive quality control system to provide high-purity, low-endotoxin oligonucleotide products from nmol to kilogram scale for nucleic acid drug development from CRO to CDMO, enabling end-to-end support for small nucleic acid therapeutics development.

Product Advantages 

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Product List

  • Custom Synthesis

    siRNA                   ASO            miRNA            Aptamer              sgRNA

  • Off-the-Shelf Products
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Modification and Conjugation Platforms

  • Modification Capabilities

    Supports over 200+ chemical modifications, including MOE, 2′-O-Methyl, 2′-Fluoro, phosphorothioate (PS), and more.

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  • Conjugation Types Capabilities

    BiOligo provides diverse molecular conjugation strategies, enabling oligonucleotide conjugation with antibodies, peptides, small molecules, and other functional moieties to support various conjugation approaches.

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  • Quality Control

    BiOligo provides 100+ quality control methods covering structural characterization, purity analysis, water content, endotoxin testing, osmolality, free acid content, sodium ion quantification, viscosity analysis, trace pH measurement, and more. Customized QC solutions can be tailored based on modification types, modification stereochemistry, and development stage requirements.

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