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NGS Oligos

Next-generation sequencing (NGS) workflows require high-quality oligonucleotides for library construction, indexing, and target enrichment. At BiOligo, we provide custom NGS oligonucleotides — including adapters, barcodes, panels and blockers for different experimental workflows, including library construction, target enrichment, multiplex PCR, and custom panel design.

Whether you need ready-to-use products or fully customized sequences, our oligos ensure accuracy, reproducibility, and platform compatibility.

Our NGS Oligo Products

Adapters

BiOligo provides comprehensive solutions for indexed library preparation. Adapters are available in full-length, truncated, and UMI formats.
  • Index lengths of 8 nt or 10 nt
  • Multiplexing capacity of up to 1,536 unique dual indexes (UDI)
  • Exceptional purity and low error rates, with cross-contamination as low as 0.01%
Types Index lengths Purification Method Delivery Formats Pack Formats
Adapters 8 nt / 10 nt DSL, PAGE or HPLC Lyophilized powder
or liquid solution		 Tubes or plates

Blockers

BiOligo provides standard and custom-designed blockers to minimize index hopping and reduce non-specific hybridization.
  • High Capture Efficiency
  • Compatible with various hybrid capture platforms
  • Customizable Solutions
Types Index lengths Purification Method Delivery Formats Pack Formats
Blockers 8 nt / 10 nt DSL, PAGE or HPLC Lyophilized powder
or liquid solution		 Tubes or plates

Panels

BiOligo offers both ready-to-use capture probe sets and fully customized panels for target enrichment workflows. Our SmartBaits™ design platform enables precise, high-efficiency probe design by optimizing GC balance, specificity, and structural stability. Flexible input formats (BED, FASTA, GeneSymbol) and adjustable tiling densities ensure accurate coverage across diverse genomes. With refined algorithms and spike-in compatibility, SmartBaits™ panels deliver uniform capture performance while minimizing probe numbers and cost.
  • Explore stocked panels: Link.
  • Request a custom design, please contact our sales team: hernando.tang@bioligo.com.