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Gene Therapy

In living organisms, gene silencing caused by siRNA, miRNA, and ASO-mediated RNA interference (RNAi) is an important form of gene expression regulation that specifically initiates target mRNA degradation or protein translation expression inhibition, thereby reducing gene expression and function.

 

Since RNAi targets are upstream mRNA, lncRNA, circRNA, miRNA and other RNA molecules, and there is a diversity of upstream and downstream gene action mechanisms, RNAi has the advantage of being able to achieve many small molecules and monoclonal antibodies that cannot become drugs, such as targets with complex or unclear protein structures, targets with shear mutations, lncRNA, circRNA, miRNA-regulated targets, etc. Currently, hundreds of RNAi drugs have entered clinical studies worldwide, and several siRNAs have been approved, which will lead the wave of new drug development in the next 10 years.

 

For this reason, BiOligo has launched a variety of RNA/DNA regulatory mininucleic acid products (including conventional mininucleic acid products and special sequence and optimized mininucleic acid products) such as siRNA (small interfering RNA), ASO (antisense oligonucleotide), miRNA mimics/inhibitor/agomir/antagomir, etc. to help genetic research and drug target development.


 

siRNA

miRNA

ASO

shRNA vector construction

CpG adjuvant




Service Details

RNAi Library

S/N

Services

Specification

PR010

Customized siRNA library

0.25nmol

PR011

Human Genome siRNA Premix Library

0.25nmol*2.2 coding genes

PR012

RBP siRNA library

0.25nmol*1199 important RBP genes of siRNA library

PR013

Kinase

0.25nmol*499 important Kinase genes of siRNA library

PR014

Phosphtases

0.25nmol*218 important Phosphtases genes of siRNA library

PR015

Chemokine Receptors

0.25nmol*12 important Kinase genes of siRNA library

PR016

Proteases gene

0.25nmol*590 important Kinase genes of siRNA library

PR017

Metastasis gene

0.25nmol*150 important Kinase genes of siRNA library

PR018

Apoptosis

0.25nmol*532 important Kinase genes of siRNA library

PR019

Transcription factors

1nmol*5457

PR020

Human Epigenetics siRNA Library

1nmol*1563

PR021

BLG Drug Select Human drug-targeted siRNA library (384-well)

1nmol*23778



RNAi Service

S/N

Services

Specification

PR022

Effective   target screening validation services

3-choice 1 target screening validation service WB and qPCR

PR023

Cell function validation services

Each per item