siRNA

Small interfering RNA (siRNA) offers the simplest and fastest way to achieve gene silencing in cells or in vivo, making it a key strategy in RNAi-based therapeutics. However, a significant challenge remains: designing effective siRNAs that deliver strong target knockdown with minimal off-target effects.
At BiOligo, we make RNAi easy, effective, and worry-free:

High knockdown efficiency

By leveraging our proprietary algorithm, which optimizes thermodynamics and filters sequences, we can enhance knockdown efficiency and minimize off-target risk. Further supported by our synthesis platform, which offers over 200 modification options, giving you flexible customization to boost both siRNA specificity and knockdown performance.

Flexible Packages

Whatever your project demands, you can choose from our comprehensive, end-to-end solutions or select specific individual services, such as design, synthesis, or functional validation.
  • Looking for guaranteed results? Our Guarantee Packages are for you. Just tell us your target gene and species, and we'll provide functional RNAi that's proven to work. This means you'll save time, cut costs, and avoid the risk of experimental setbacks.
    • For instance, our siRNA Guarantee Package (1/3) includes three pre-designed siRNAs, and we guarantee that at least one will achieve over 70% silencing efficiency.

Cost-effective solution

Why settle for overpriced siRNA and slow service? BiOligo offers 24/7 expert technical support and a hassle-free ordering experience, providing high-quality siRNA at a budget-friendly price.

Cases

Australia – Hospital Client

All three siRNA sequences delivered demonstrated >85% knockdown efficiency, confirming reliable and effective gene silencing.