Custom Panels
BiOligo provides fully integrated panel design and synthesis services, specifically optimized for GC-rich, repetitive, and structurally complex genomic regions. Our solutions are trusted by leading researchers for their high success rate and reproducibility.
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Smart Probe Design Platform: Accepts BED, FASTA, or GeneSymbol input, and automatically optimizes GC content, avoids problematic secondary structures, and reduces dimer formation.
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Efficient Coverage, Lower Cost: Achieves high on-target rates with fewer probes, leading to greater cost-efficiency.
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Flexible Tiling & Expansion: Supports 1×/2×/overlapping probe density and allows for easy spike-in of new targets.
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High-Quality Synthesis: Probes are produced with exceptional quality and purity, ensuring uniform hybridization performance.
We also offer ready-to-use disease-focused panels. Our lung cancer panel, for instance, targets over 70 key genes with high coverage across mutation hotspots, fusions, and CNV regions, enabling precise profiling for both clinical and translational research.
Product Data
Superior Capture Performance
A panel was designed using Bioligo SmartBaits and LXX’s method to target the coding DNA sequence (CDS) regions of the KRAS, ALK, ROS1, EGFR, and BRAF genes. Under identical conditions, the SmartBaits demonstrated higher enrichment efficiency and better target coverage. This resulted in more effective use of sequencing data and improved sensitivity for detecting genetic variants.
Improved Coverage
Based on a panel originally designed by competitor IXX, Bioligo SmartBaits used its proprietary algorithm to design spike-in probes. These probes specifically targeted difficult, high-repeat regions that were previously left uncovered. This significantly improved both coverage and capture efficiency, allowing for a more complete analysis of the target region and enhancing the reliability of subsequent variant detection.
